10 exam-style questions with answers and explanations. Tap an answer to check yourself. When you're ready, take the scored version in the free practice test.
The TCTCN exam has 165 questions and runs 3 hours.
These 10 free TCTCN questions are organized by exam domain, so you can see how each part of the Transplantation and Cellular Therapy Certified Nurse blueprint is tested. Reveal the answer and explanation under each question.
A nurse is preparing a patient for an autologous hematopoietic stem cell transplant. When teaching, the nurse explains that, compared with an allogeneic transplant, the autologous approach:
Correct answer: D - Does not produce a graft-versus-tumor effect
A patient asks how chimeric antigen receptor (CAR) T-cell therapy works. Which explanation is accurate?
Correct answer: C - The patient's own T cells are engineered to target a tumor antigen
Compared with peripheral blood stem cells, umbilical cord blood as a graft source is characterized by:
Correct answer: B - Greater tolerance of HLA mismatch but a limited cell dose
The graft-versus-leukemia effect that helps prevent relapse after allogeneic transplantation is mediated by:
Correct answer: C - Donor immune cells that recognize and attack malignant cells
A patient is receiving high-dose cyclophosphamide as part of the conditioning regimen. Which intervention is MOST important to prevent hemorrhagic cystitis?
Correct answer: A - Administering mesna with aggressive hydration
Which conditioning agent is associated with a risk of seizures, requiring seizure prophylaxis during administration?
Correct answer: B - Busulfan
Lymphodepleting chemotherapy is given before a chimeric antigen receptor (CAR) T-cell infusion PRIMARILY to:
Correct answer: D - Promote expansion and persistence of the infused CAR T cells
During infusion of a thawed cryopreserved autologous stem cell product, a patient reports nausea and a garlic-like taste. These findings are MOST likely related to:
Correct answer: C - The cryoprotectant dimethyl sulfoxide (DMSO)
A patient's absolute neutrophil count has been above 500/mm3 for three consecutive days. The nurse documents this as:
Correct answer: A - Neutrophil engraftment
A patient develops acute graft-versus-host disease on day +30 after an allogeneic transplant. Which is the FIRST-line treatment?
Correct answer: A - Systemic corticosteroids
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